Journal of Medicine, Radiology, Pathology and Surgery


Vetting of selected dental anomalies associated with anterior teeth

C. Supreetha, S. V. Sreelatha

[Year:2017] [Month:May-June] [Volume:4 ] [Number:3] [Pages No:1–5] [No. of Hits: 217]

  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jmrps.92]


Background: Dental anomalies can lead to various complications. Screening of subjects at an early age to detect these anomalies if present, which can be managed by simple treatment options, may prevent complicated treatment procedures at a later date.

Aims and Objectives: The aim of this study was to evaluate the prevalence of dental anomalies associated with the anterior teeth in the permanent dentition, of individuals with age group ranging between 19 and 24 years without any syndromes.

Materials and Methods: A total of 265 cases were screened for any defects associated with the upper and lower anterior teeth. We carried out a thorough clinical examination to analyze the prevalence of microdontia, macrodontia, talon cusp, fusion, dens invaginatus, transposition, retained deciduous teeth, and supernumerary teeth.

Results: Our study included 265 subjects, out of which 39 cases presented with dental anomalies were recorded. The common dental anomalies found in the group were as follows: 8% of cases with congenitally missing teeth, 1.71% of cases with supernumerary teeth, 5.71% with macrodontia, 5.71% with microdontia, and 1.14% retained deciduous teeth.

Conclusion: Developmental dental anomalies are evident clinically, which result in different dental deformities. The pursuit of the present study was to determine the frequency with which various developmental dental anomalies in anterior teeth occur in non-syndromic patients. It was seen that these anomalies did not vary much between the males and females. Macrodontia, supernumerary teeth, peg-shaped lateral incisors (microdontia), and congenital missing teeth outnumbered the other dental anomalies in our study. Attentive observation and applicable investigations are needed to diagnosticate the condition and regulate pertinent treatment. Antecedent diagnosis can result in early intervention and treatment if necessary.

Keywords: Anterior teeth, macrodont

How to cite this article: Supreetha C, Sreelatha SV. Vetting of selected dental anomalies associated with anterior teeth. J Med Radiol Pathol Surg 2017;4:1-5.

Received: 10 February 2017;

Accepted: 28 March 2017


Liver biopsy to the aid in diagnosis of pediatric hemophagocytic lymphohistiocytosis: A case report

K. R. Chatura, Bhargavi Mohan

[Year:2017] [Month:May-June] [Volume:4 ] [Number:3] [Pages No:6–9] [No. of Hits: 232]

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  • [Abstract]
  • [DOI : 10.15713/ins.jmrps.93]


Hemophagocytic lymphohistiocytosis is a life-threatening, macrophage-related hyperinflammatory disorder that presents with sepsis like syndrome. The clinical presentation, laboratory findings, and histopathological features can be variable and nonspecific, and considerable overlap with other disorders is observed. Since hepatomegaly and hepatic dysfunction occur early in the disease, demonstration of hemophagocytosis in liver biopsy facilitated the diagnosis in our case, which was missed earlier on bone marrow aspiration study for pancytopenia

Keywords: Hemophagocytic lymphohistiocytosis, liver biopsy, pancytopenia

How to cite this article: Chatura KR, Mohan B. Liver biopsy to the aid in diagnosis of pediatric hemophagocytic lymphohistiocytosis: A case report. J Med Radiol Pathol Surg 2017;4:6-9.

Received: 07 April 2017;

Accepted: 26 May 2017


Extragingival pyogenic granuloma on the tongue: A rare case report and review of literature

Tejavathi Nagaraj, Keerthi Irugu, Durga Rajaram Okade, Swathi Saxena

[Year:2017] [Month:May-June] [Volume:4 ] [Number:3] [Pages No:10–13] [No. of Hits: 219]

  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jmrps.94]


Pyogenic granuloma is a benign oral soft tissue inflammatory hyperplasia. It occurs as a tumor-like proliferation of the oral mucosa, which usually seen in response to nonspecific infection. Due to its high frequency in the oral cavity, this is a case of pyogenic granuloma in a male patient aged 13 years which occurred on the lateral border of tongue. Clinical and histopathologic features and also differential diagnosis are mentioned in this case report which helps in the treating the lesion and also reducing the chances of recurrence.

Keywords: Hyperplasia, pyogenic granuloma, recurrence

How to cite this article: Nagaraj T, Irugu K, Okade DR, Saxena S. Extragingival pyogenic granuloma on the tongue: A rare case report and review of literature. J Med Radiol Pathol Surg 2017;4:10-13.

Received: 17 April 2017;

Accepted: 28 May 2017


Immunopathogenesis of pemphigus vulgaris: A brief review

K. Lizbeth Raju, K. Shwetha Nambiar, Vanishri C. Haragannavar, Dominic Augustine, S. V. Sowmya, Roopa S. Rao

[Year:2017] [Month:May-June] [Volume:4 ] [Number:3] [Pages No:14–16] [No. of Hits: 281]

  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jmrps.95]


Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membrane. It is mediated by autoantibody against desmoglein 3, an intracellular adhesion glycoprotein that forms a part of desmosome. Loss of tolerance to this autoantigen happens for a still unknown reason. However, this disease has a very strong association with some human leukocyte antigen molecules whose structure favors the binding of certain peptide of desmoglein 3. The mechanism of the action of autoantibody has turned out to be more complicated than it was thought, and it is not well established yet. Nevertheless, in the past few years, important discoveries have been made that point to a role of autoantibodies in staining different signaling cascades that lead to loss of adhesion between keratinocyte and death of these cells resulting in acantholysis as histologic manifestation and blister as clinical manifestation.

Keywords: Acantholysis, apoptolysis, desmoglein, pemphigus vulgaris

How to cite this article: Raju KL, Nambiar KS, Haragannavar VC, Augustine D, Sowmya SV, Rao RS. Immunopathogenesis of pemphigus vulgaris: A brief review. J Med Radiol Pathol Surg 2017;4:14-16.

Received: 11 March 2017;

Accepted: 20 May 2017


Molar incisor hypomineralization: An update

Atul Singh, Neerja Singh, Madhulika Srivastava, Rehan Khan, Pratik Kariya, Ahsan Abdullah

[Year:2017] [Month:May-June] [Volume:4 ] [Number:3] [Pages No:17–21] [No. of Hits: 341] [No. of Citation: 1]

  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jmrps.96]


Molar incisor hypomineralization (MIH) is a congenital disease which is increasing in prevalence. It affects permanent first molars and, often to a lesser degree, permanent incisors with variable severity. The etiology is unknown, but various risk factors have been put forward. Differential diagnosis is mandatory not to confound MIH with other diseases such as amelogenesis imperfecta or fluorosis. Treatment consists in a minimally invasive approach by reinforcing and protecting the existing dental structure. In more severe cases, restorative treatment or extraction may be indicated.

Keywords: Dental enamel hypoplasia, hypoplastic enamel, molar incisor hypomineralization

How to cite this article: Singh A, Singh N, Srivastava M, Khan R, Kariya P, Abdullah A. Molar incisor hypomineralization: An update. J Med Radiol Pathol Surg 2017;4:17-21.

Received: 10 May 2017;

Accepted: 11 June 2017


Oral manifestation of genodermatoses

L. Kavya, S. Vandana, Swetha Paulose, Vishwanath Rangdhol, W. John Baliah, T. Dhanraj

[Year:2017] [Month:May-June] [Volume:4 ] [Number:3] [Pages No:22–27] [No. of Hits: 237] [No. of Citation: 1]

  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jmrps.97]


Genodermatoses are inherited dermatological disorders associated with the structure and functions of skin and its appendages. Several genodermatoses presenting with multisystem involvement lead to increased morbidity and mortality. Dermatological diseases, besides including the skin and its supplements may also involve the oral cavity, which deserves special attention considering that they may be the only presenting sign of these disorders. The important aspect to be noted about these disorders is the rarity of the conditions and lack of awareness among the population which are the major drawbacks in the early diagnosis and prompt management of these diseases. This review intends to outline various genodermatoses with their characteristic oral manifestations.

Keywords: Genodermatoses, mutation, oral manifestation

How to cite this article: Kavya L, Vandana S, Paulose S, Rangdhol V, Baliah WJ, Dhanraj T. Oral manifestation of genodermatoses. J Med Radiol Pathol Surg 2017;4:22-27.

Received: 11 April 2017;

Accepted: 15 May 2017