Journal of Medicine, Radiology, Pathology and Surgery

ORIGINAL ARTICLE

P. Rashmi, K. K. Suresh, K. R. Chatura

Correlation of modified Anneroth's histological grading system with E-cadherin expression in squamous cell carcinoma of oral cavity and oropharynx

[Year:2019] [Month:July-August] [Volume:6 ] [Number:4] [Pages No:1-6]


ABSTRACT


Background: E-cadherin, a cell-cell adhesion molecule, is an ""Invasion suppressor."" Loss of E-cadherin expression is associated with loss of epithelial differentiation and acquisition of metastatic potential in cancers of epithelial origin.

Objectives: The objectives of the study were to evaluate the correlation between the E-cadherin immunoreactivity score (IRS) and modified Anneroth's histological parameters and grade groups of squamous cell carcinoma (SCC) of oral cavity (OC) and oropharynx (OP).

Materials and Methods: Histomorphological grading was done using modified Anneroth's grading system in 50 cases of SCC of OC and OP and tumors were categorized into three groups. E-cadherin immunomarker was evaluated for its proportion and intensity of expression in the tumor cells and the scores were correlated with histological scores by Pearson's correlation coefficient (r).

Results: Histological parameters such as reduced keratinization, higher grade of nuclear pleomorphism, and worst pattern of invasion (WPOI) were found to be strongly associated with reduced E-cadherin expression. Overall, with worsening histological grade groups, the E-cadherin expression in the tumor was seen declining (P = 0.0000063). The histological scores were inversely related to E-cadherin IRS (r = -0.83229).

Conclusion: The study found that WPOI, nuclear pleomorphism, and degree of keratinization are important histological parameters in grading the SCC in incisional biopsies. However, the prognostic significance could not be elucidated in our study. We found that with the worsening of above parameters and histological grade of the tumor, the E-cadherin expression was reduced indicating the loss of epithelial phenotype in the tumor cells of higher grade.

Keywords: Squamous cell carcinoma, Anneroth's histological grading system, e-cadherin, oral cavity, oropharynx

How to cite this article: Rashmi P, Suresh KK, Chatura KR. Correlation of modified Anneroth's histological grading system with E-cadherin expression in squamous cell carcinoma of oral cavity and oropharynx. J Med Radiol Pathol Surg 2019;6(4):1-6

Received: 18 July 2019;

Accepted: 25 August 2019


How to cite this article: Rashmi P, Suresh KK, Chatura KR. Correlation of modified Anneroth's histological grading system with E-cadherin expression in squamous cell carcinoma of oral cavity and oropharynx. J Med Radiol Pathol Surg 2019;6(4):1-6

CASE REPORT AND REVIEW

Priyanka Acharya, Jawahar Anand, B. A. Sahana, Anil Desai

Rare simultaneous occurrence of vascular malformation of tongue and odontogenic keratocyst of anterior mandible - A case report and review of literature

[Year:2019] [Month:July-August] [Volume:6 ] [Number:4] [Pages No:7-11]


ABSTRACT


Oral cavity is mother of mysteries often revealed as an incidental finding, vascular malformation (VM) and cystic lesions to name a few. The term VM describes a variety of developmental vascular anomalies with great progress been made in the classification and understanding of these vascular lesions till date. With head and neck regions, accounting for about 60% and buccal (31%), aural (16%), nasal (11%) mandibular (5%), and maxillary (4%) regions being common site of occurrence in terms of frequency. VMs are further characterized by the predominantly affected vessel (arterial, venous, lymphatic, capillary - individually or combined) and subclassified into truncular and extratruncular vessels. Staging systems based on escalating clinical symptoms or anatomic extent have been developed by Schöbinger (for arteriovenous malformations) and has undergone several modifications in original Mulliken classification which was recently expanded and updated to incorporate new entities, genetic information, and syndromes till date. Cystic lesions of orofacial region are usually asymptomatic until secondarily infected, thereby early diagnosis, and management is of prime concern before the disease process has attained a stage of irreversibility and permanent damage. Odontogenic keratocyst (OKC) was first described by Philipsen in 1956 and has undergone numerous changes in nomenclature by the World Health Organization as primodial cyst to keratocystic odontogenic tumor, known for its typical aggressive presentation and high recurrence rate. We have reported a rare incidence of simultaneous occurrence of VM of tongue, along with OKC of anterior mandible in a young male with a brief review of the literature.

Keywords: Odontogenic keratocyst, platelet rich fibrin, tongue, vascular malformation

How to cite this article: Acharya P, Anand J, Sahana BA, Desai A. Rare simultaneous occurrence of vascular malformation of tongue and odontogenic keratocyst of anterior mandible - A case report and review of literature. J Med Radiol Pathol Surg 2019;6(4):7-11

Received: 19 July 2019;

Accepted: 26 August 2019


How to cite this article: Acharya P, Anand J, Sahana BA, Desai A. Rare simultaneous occurrence of vascular malformation of tongue and odontogenic keratocyst of anterior mandible - A case report and review of literature. J Med Radiol Pathol Surg 2019;6(4):7-11

CASE REPORT

Annapoorna Yogish Pai, Lauren Parker

Genial tubercle fracture: What do we need to know?

[Year:2019] [Month:July-August] [Volume:6 ] [Number:4] [Pages No:12-13]


ABSTRACT


Genial tubercle fractures are rare. They can occur as an isolated fracture or with other fractures of the mandible, particularly symphyseal fractures. The diagnosis can be difficult in an isolated fracture, as standard radiographs for mandibular fractures, orthopantomogram and posteroanterior mandible, will not show the fractured tubercles. A computed tomography scan would be the standard investigation of choice for diagnosis. However, it is not unusual to make a radiological diagnosis of salivary gland calculi or a foreign body in the floor of mouth giving rise to unnecessary surgical intervention. The incidence of isolated genial tubercle fractures is higher in elderly individuals with multiple comorbidities. Hence, it becomes more imperative for oral and maxillofacial surgeons to diagnose this condition to avoid unnecessary surgery, for a condition that can be managed conservatively.

Keywords: Genial tubercle fracture, mandibular fracture, parasymphyseal fracture

How to cite this article: Pai AY, Parker L. Genial tubercle fracture: What do we need to know? J Med Radiol Pathol Surg 2019;6(4):12-13.

Received: 21 July 2019;

Accepted: 26 August 2019


How to cite this article: Pai AY, Parker L. Genial tubercle fracture: What do we need to know? J Med Radiol Pathol Surg 2019;6(4):12-13.

CASE REPORT

Tejavathi Nagaraj, Soniya Kongbrailatpam, Ijum Doye, Devu Krishnan

Torus mandibularis: A case report

[Year:2019] [Month:July-August] [Volume:6 ] [Number:4] [Pages No:14-15]


ABSTRACT


Torus mandibularis is an extra growth of bone mostly detected on the lingual aspect of the mandible which could be single or many. It is asymptomatic and sometimes result in complications include speech disturbance, position of tongue, prosthodontic treatment, poor oral care, and traumatic ulceration. It is roughly calculated that 10% of the people of United States shows mandibular tori. This case report is to present bilateral mandibular tori and its clinical features.

Keywords: Bony exostosis, tori, torus mandibularis

How to cite this article: Nagaraj T, Kongbrailatpam S, Doye I, Krishnan D. Torus mandibularis: A case report. J Med Radiol Pathol Surg 2019;6(4):14-15.

Received: 22 July 2019;

Accepted: 28 August 2019


How to cite this article: Nagaraj T, Kongbrailatpam S, Doye I, Krishnan D. Torus mandibularis: A case report. J Med Radiol Pathol Surg 2019;6(4):14-15.

CASE REPORT

C. Madhukar Nayaka, Sujata Byahatti, Renuka Ammanagi

Can tamarind seed chewing cause oral submucous fibrosis - A case report

[Year:2019] [Month:July-August] [Volume:6 ] [Number:4] [Pages No:16-17]


ABSTRACT


Oral submucous fibrosis is a chronic disease of insidious onset feature of the deposition of fibrous tissue in the submucous layer of the palate, fauces, cheek, lips, pharynx, and esophagus which also affect muscles of mastication resulting in trismus and disability due to muscle hypertrophy highly widespread in the Indian subcontinent and mainly caused by areca nut chewing and other irritants in various forms. It is a potentially cruel condition and is of major concern to oral physicians. The multifactorial nature of this disorder is discussed in past literature. Still now, only one case paper published on tamarind that this is the second paper which presents a case of oral submucous fibrosis in 45 years female patient who had tamarind seed chewing habit.

Keywords: Alkaloids, coppers, oral submucous fibrosis, tamarind seeds tannins

How to cite this article: Nayaka CM, Byahatti S, Ammanagi R. Can tamarind seed chewing cause oral submucous fibrosis – A case report. J Med Radiol Pathol Surg 2019;6(4):16-3

Received: 24 July 2019;

Accepted: 25 August 2019


How to cite this article: Nayaka CM, Byahatti S, Ammanagi R. Can tamarind seed chewing cause oral submucous fibrosis – A case report. J Med Radiol Pathol Surg 2019;6(4):16-3